Predictive Factors for Prolonged Urination Disorder After Permanent 125I Brachytherapy for Localized Prostate Cancer

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Bibliographic Information

Title
Predictive Factors for Prolonged Urination Disorder After Permanent 125I Brachytherapy for Localized Prostate Cancer
Other Title
  • 限局性前立腺癌に対するI-125　シード線源永久挿入による排尿障害予測因子
  • Predictive Factors for Prolonged Urination Disorder After Brachytherapy
Author
Mori, Hidehisa
Alias Name
  • 森, 英恭
  • モリ, ヒデヒサ
Author
Fukumori, Tomoharu
Alias Name
  • 福森, 知治
  • フクモリ, トモハル
Author
Daizumoto, Kei
Alias Name
  • 大豆本, 圭
  • ダイズモト, ケイ
Author
Tsuda, Megumi
Alias Name
  • 津田, 恵
  • ツダ, メグミ
Author
Kusuhara, Yoshito
Alias Name
  • 楠原, 義人
  • クスハラ, ヨシト
Author
Fukawa, Tomoya
Alias Name
  • 布川, 朋也
  • フカワ, トモヤ
Author
Yamamoto, Yasuyo
Alias Name
  • 山本, 恭代
  • ヤマモト, ヤスヨ
Author
Yamaguchi, Kunihisa
Alias Name
  • 山口, 邦久
  • ヤマグチ, クニヒサ
Author
Takahashi, Masayuki
Alias Name
  • 高橋, 正幸
  • タカハシ, マサユキ
Author
Kubo, Akiko
Alias Name
  • 久保, 亜貴子
  • クボ, アキコ
Author
Kawanaka, Takashi
Alias Name
  • 川中, 崇
  • カワナカ, タカシ
Author
Furutani, Shunsuke
Alias Name
  • 古谷, 俊介
  • フルタニ, シュンスケ
Author
Ikushima, Hitoshi
Alias Name
  • 生島, 仁史
  • イクシマ, ヒトシ
Author
Kanayama, Hiro-omi
Alias Name
  • 金山, 博臣
  • カナヤマ, ヒロオミ
University
徳島大学
Types of degree
博士（医学）
Grant ID
甲医第1419号
Degree year
2019-05-23

Description

Background: We assessed the change in LUTS after prostate brachytherapy to reveal factors for prolonged urination disorder. Materials and Methods: Four hundred and fourpatients received prostate brachytherapy at our institution and were followed-up for at least 2 years. We evaluated the correlation of mean IPSS changes and clinical factors. Using multivariate analysis, we also evaluated clinical factors with potential to delay IPSS resolution. Results: In cases with prostate volume more than 30 cm3, radiation dose to 90% of prostate volume (D90) more than 160 Gy, and radiation dose to 30% of the urethral volume (UD30) more than 240 Gy, mean IPSS levels were significantly higher, even 30 months after treatment. On multivariate analysis, baseline IPSS more than 8 points and D90 more than 160 Gy were significant predictors for delayed IPSS resolution. Conclusion: Our data suggest that higher baseline IPSS and higher D90 were predictors for prolonged urination disorder.

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