Bone marrow-derived fibrocytes promote stem cell-like properties of lung cancer cells

DOI 機関リポジトリ NDLデジタルコレクション

書誌事項

タイトル
Bone marrow-derived fibrocytes promote stem cell-like properties of lung cancer cells
タイトル別名
  • 骨髄由来線維細胞は肺がん細胞のがん幹細胞様特性を増強する
著者
西條, 敦郎
著者別名
  • サイジョウ, アツロウ
  • Saijo, Atsuro
著者
後東, 久嗣
著者別名
  • ゴトウ, ヒサツグ
  • Goto, Hisatsugu
著者
ナカノ, マユリ
著者別名
  • Nakano, Mayuri
著者
ミツハシ, アツシ
著者別名
  • Mitsuhashi, Atsushi
著者
青野, 純典
著者
埴淵, 昌毅
著者別名
  • ハニブチ, マサキ
  • Hanibuchi, Masaki
著者
小川, 博久
著者別名
  • オガワ, ヒロヒサ
  • Ogawa, Hirohisa
著者
上原, 久典
著者別名
  • ウエハラ, ヒサノリ
  • Uehara, Hisanori
著者
近藤, 和也
著者別名
  • コンドウ, カズヤ
  • Kondo, Kazuya
著者
西岡, 安彦
著者別名
  • ニシオカ, ヤスヒコ
  • Nishioka, Yasuhiko
学位授与大学
徳島大学
取得学位
博士（医学）
学位授与番号
甲医第1365号
学位授与年月日
2018-03-20

説明

Cancer stem cells (CSCs) represent a minor population that have clonal tumor initiation and self-renewal capacity and are responsible for tumor initiation, metastasis, and therapeutic resistance. CSCs reside in niches, which are composed of diverse types of stromal cells and extracellular matrix components. These stromal cells regulate CSC-like properties by providing secreted factors or by physical contact. Fibrocytes are differentiated from bone marrow-derived CD14þ monocytes and have features of both macrophages and fibroblasts. Accumulating evidence has suggested that stromal fibrocytes might promote cancer progression. However, the role of fibrocytes in the CSC niches has not been revealed. We herein report that human fibrocytes enhanced the CSC-like properties of lung cancer cells through secreted factors, including osteopontin, CC-chemokine ligand 18, and plasminogen activator inhibitor-1. The PIK3K/AKT pathway was critical for fibrocytes to mediate the CSC-like functions of lung cancer cells. In human lung cancer specimens, the number of tumor-infiltrated fibrocytes was correlated with high expression of CSC-associated protein in cancer cells. These results suggest that fibrocytes may be a novel cell population that regulates the CSC-like properties of lung cancer cells in the CSC niches.

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ