Conditional Deletion of Smad1 Ameliorates Glomerular Injury in Progressive Glomerulonephritis
書誌事項
- タイトル
- Conditional Deletion of Smad1 Ameliorates Glomerular Injury in Progressive Glomerulonephritis
- タイトル別名
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- Smad1の条件付き遺伝子削除は進行性糸球体腎炎による糸球体傷害を改善する
- 著者
- 荒木, 真
- 著者別名
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- アラキ, マコト
- Araki, Makoto
- 著者
- マツバラ, タケシ
- 著者別名
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- Matsubara, Takeshi
- 著者
- 安部, 秀斉
- 著者別名
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- アベ, ヒデハル
- Abe, Hideharu
- 著者
- トリコシ, カズオ
- 著者別名
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- Torikoshi, Kazuo
- 著者
- 美馬, 晶
- 著者別名
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- ミマ, アキラ
- Mima, Akira
- 著者
- イエハラ, ノリユキ
- 著者別名
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- Iehara, Noriyuki
- 著者
- フカツ, アツシ
- 著者別名
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- Fukatsu, Atsushi
- 著者
- キタ, トオル
- 著者別名
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- Kita, Toru
- 著者
- アライ, ヒデノリ
- 著者別名
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- Arai, Hidenori
- 著者
- 土井, 俊夫
- 著者別名
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- ドイ, トシオ
- Doi, Toshio
- 学位授与大学
- 徳島大学
- 取得学位
- 博士（医学）
- 学位授与番号
- 乙医第1752号
- 学位授与年月日
- 2017-11-30
説明
Matrix expansion and cell proliferation are concomitantly observed in various glomerular injuries. However, the molecular mechanisms responsible for these changes have not been fully elucidated. We have reported that Smad1 is a key signalling molecule that regulates the transcription of type IV collagen (Col4) in mesangial matrix expansion and is thereby involved in glomerular injury in an acute model of glomerulonephritis. In this study, we addressed the role of Smad1 signalling in accelerated nephrotoxic nephritis (NTN), a model of progressive glomerulonephritis, using conditional deletion of Smad1 in Rosa26CreERT2 mice (Smad1-CKO). Mesangial matrix expansion in the Smad1-CKO mice with NTN was significantly inhibited compared with that in wild type mice with NTN, which was consistent with the decrease in Col4 expression level. On the other hand, STAT3 activation and cell proliferation were not influenced by Smad1 deletion in the NTN model. Therefore, we investigated another factor that activates cell proliferation in the absence of Smad1. Id2 induced VEGF secretion and subsequent STAT3 activation, independently of Smad1 expression in mouse mesangial cells. Here we show that Smad1 plays an important role in the development of glomerular injury without affecting cell proliferation, in progressive glomerulonephritis.
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詳細情報 詳細情報について
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- CRID
- 1910867133858630528
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- NII論文ID
- 500001621247
- 500001051342
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- 本文言語コード
- en
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- データソース種別
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- IRDB
- NDLサーチ