Role of zinc in intestinal-pancreatic circulation and pancreatic function

KAKEN

About This Project

Japan Grant Number
JP16K09393 (JGN)
Funding Program
Grants-in-Aid for Scientific Research
Funding Organization
Japan Society for the Promotion of Science

Kakenhi Information

Project/Area Number
16K09393
Research Category
Grant-in-Aid for Scientific Research (C)
Allocation Type
  • Multi-year Fund
Review Section / Research Field
  • Biological Sciences > Medicine, Dentistry, and Pharmacy > Clinical internal medicine > Gastroenterology
Research Institution
  • Nagoya University
Project Period (FY)
2016-04-01 〜 2019-03-31
Project Status
Completed
Budget Amount*help
4,810,000 Yen (Direct Cost: 3,700,000 Yen Indirect Cost: 1,110,000 Yen)

Research Abstract

Zinc ion resides is the active center of many types of proteins and zinc deficiency leads to various disorders in the body. The Zn ions, which are not bound to proteins, have metal toxicity such as inhibition of ion channels. Zinc exhibits a characteristic intestinal-pancreatic circulation that zinc is absorbed in the small intestine and excreted mainly in the pancreatic juice. The relationship between zinc deficiency and exocrine pancreatic dysfunction has long been known, but the mechanism is largely unknown. In this study, we examined the direct effects of zinc ion on the physiological function of pancreatic duct cells and the expression of zinc transporter (Zip and ZnT) in pancreas.

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