Development of Asymmetric Organic Catalysts Using Accurate and Efficient Conformational Analysis
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- Kamachi Takashi
- Principal Investigator
- 福岡工業大学
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- 山本 英治
- Co-Investigator
- 九州大学
About this project
- Japan Grant Number
- JP18H01969
- Funding Program
- Grants-in-Aid for Scientific Research
- Funding organization
- Japan Society for the Promotion of Science
- Project/Area Number
- 18H01969
- Research Category
- Grant-in-Aid for Scientific Research (B)
- Allocation Type
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- Single-year Grants
- Review Section / Research Field
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- Basic Section 33010:Structural organic chemistry and physical organic chemistry-related
- Research Institution
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- Fukuoka Institute of Technology
- Project Period (FY)
- 2018-04-01 〜 2023-03-31
- Project Status
- Completed
- Budget Amount*help
- 17,160,000 Yen (Direct Cost: 13,200,000 Yen Indirect Cost: 3,960,000 Yen)
Research Abstract
Organocatalysts are ideal catalysts that are free from toxic heavy metal residues and can address the issues of rising rare metal prices and depletion. In this study, we have developed a variety of conformational analysis methods to elucidate the causes of enantioselectivity of organocatalysts. We used our own ConFinder program to perform fast and accurate conformational analysis. This program allows us to elucidate the specific conformations responsible for the high selectivity, providing hints for the analysis of reaction mechanisms and the design of catalysts. In collaboration with an experimental group developing organocatalysts, we conducted research on asymmetric hydrolysis reactions of esters.
Details 詳細情報について
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- CRID
- 1040000781992962432
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- Text Lang
- ja
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- Data Source
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- KAKEN