The tooth germ is formed utilizing induction of Epithelial to Mesenchymal Transition (EMT) from epithelium
About this project
- Japan Grant Number
- JP18H03009
- Funding Program
- Grants-in-Aid for Scientific Research
- Funding organization
- Japan Society for the Promotion of Science
- Project/Area Number
- 18H03009
- Research Category
- Grant-in-Aid for Scientific Research (B)
- Allocation Type
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- Single-year Grants
- Review Section / Research Field
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- Basic Section 57070:Developmental dentistry-related
- Research Institution
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- Tohoku University
- Project Period (FY)
- 2018-04-01 〜 2023-03-31
- Project Status
- Completed
- Budget Amount*help
- 17,290,000 Yen (Direct Cost: 13,300,000 Yen Indirect Cost: 3,990,000 Yen)
Research Abstract
Teeth are formed by the interrelationship between epithelial and mesenchymal cells. However, if epithelial-mesenchymal transition (EMT) which induces mesenchymal cells from epithelial cells is used, organ will generate from single epithelial cell. In our previous study, we found that Sox21 KO mice induce EMT. Therefore, in this study, we analyze the mechanism of EMT in hard tissue formation. At first, Sox21 was expressed in T and B cells. Therefore, when macrophages and lymphocytes with suppressed expression of Sox21 were co-cultured, osteoclast differentiation was enhanced. This indicates that while Sox21 deficiency causes EMT, it also promotes osteoclast differentiation and causes osteogenesis imperfecta-like symptoms.
Details 詳細情報について
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- CRID
- 1040000781993560960
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- Text Lang
- ja
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- Data Source
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- KAKEN