Exploration of phenomena indicative of mitochondrial dysfunction and its applications

About this project

Japan Grant Number
JP18H03180
Funding Program
Grants-in-Aid for Scientific Research
Funding organization
Japan Society for the Promotion of Science
Project/Area Number
18H03180
Research Category
Grant-in-Aid for Scientific Research (B)
Allocation Type
  • Single-year Grants
Review Section / Research Field
  • Basic Section 59040:Nutrition science and health science-related
Research Institution
  • Kyushu University
Project Period (FY)
2018-04-01 〜 2022-03-31
Project Status
Completed
Budget Amount*help
17,290,000 Yen (Direct Cost: 13,300,000 Yen Indirect Cost: 3,990,000 Yen)

Research Abstract

It has been suggested that mitochondrial dysfunction triggers the onset of aging and lifestyle-related diseases. However, a simple and reproducible method to evaluate mitochondrial dysfunction such as decreased ATP synthesis has not been found. In this study, we focused on LONP1, a protease localized in the mitochondrial matrix, and found that LONP1 functions in a manner dependent on ATP hydrolysis and that its dysfunction causes the accumulation of protein aggregates in the mitochondrial matrix. This indicates that the accumulation of protein aggregates may be an indicator of abnormal mitochondrial function accompanied by a decrease in the amount of ATP in the mitochondrial matrix.

Related Articles

See more

Related Data

See more

Related Books

See more

Related Dissertations

See more

Related Projects

See more

Related Products

See more

Details 詳細情報について

Back to top