Exploration of phenomena indicative of mitochondrial dysfunction and its applications
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- Matsushima Yuichi
- Principal Investigator
- 九州大学
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- 瀬戸山 大樹
- Co-Investigator
- 九州大学
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- 相原 正宗
- Co-Investigator
- 九州大学
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- 内海 健
- Co-Investigator
- 九州大学
About this project
- Japan Grant Number
- JP18H03180
- Funding Program
- Grants-in-Aid for Scientific Research
- Funding organization
- Japan Society for the Promotion of Science
- Project/Area Number
- 18H03180
- Research Category
- Grant-in-Aid for Scientific Research (B)
- Allocation Type
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- Single-year Grants
- Review Section / Research Field
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- Basic Section 59040:Nutrition science and health science-related
- Research Institution
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- Kyushu University
- Project Period (FY)
- 2018-04-01 〜 2022-03-31
- Project Status
- Completed
- Budget Amount*help
- 17,290,000 Yen (Direct Cost: 13,300,000 Yen Indirect Cost: 3,990,000 Yen)
Research Abstract
It has been suggested that mitochondrial dysfunction triggers the onset of aging and lifestyle-related diseases. However, a simple and reproducible method to evaluate mitochondrial dysfunction such as decreased ATP synthesis has not been found. In this study, we focused on LONP1, a protease localized in the mitochondrial matrix, and found that LONP1 functions in a manner dependent on ATP hydrolysis and that its dysfunction causes the accumulation of protein aggregates in the mitochondrial matrix. This indicates that the accumulation of protein aggregates may be an indicator of abnormal mitochondrial function accompanied by a decrease in the amount of ATP in the mitochondrial matrix.
Details 詳細情報について
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- CRID
- 1040000781993689472
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- Text Lang
- ja
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- Data Source
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- KAKEN
