Study on the metabolic effects of endocrine-disrupting chemicals on nuclear receptors
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- Matsushima Ayami
- Principal Investigator
- 九州大学
About this project
- Japan Grant Number
- JP18KK0320
- Funding Program
- Grants-in-Aid for Scientific Research
- Funding organization
- Japan Society for the Promotion of Science
- Project/Area Number
- 18KK0320
- Research Category
- Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
- Allocation Type
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- Multi-year Fund
- Review Section / Research Field
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- Integrated Disciplines > Environmental science > Environmental analyses and evaluation > Risk sciences of radiation and chemicals
- Research Institution
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- Kyushu University
- Project Period (FY)
- 2019 〜 2021
- Project Status
- Completed
- Budget Amount*help
- 14,820,000 Yen (Direct Cost: 11,400,000 Yen Indirect Cost: 3,420,000 Yen)
Research Abstract
Bisphenol A is a raw material of polycarbonate and epoxy resins. This chemical is also known as a harmful environmental chemical, which shows adverse effects even at low doses. The target molecules of environmental chemicals are thought to be nuclear receptors that control gene transcriptions. We have found that bisphenol A bound not only to estrogen receptors but also estrogen-related receptor gamma. In this study, we performed the structure-activity relationship study between bisphenol A and estrogen receptors. We also analyzed the function of estrogen-related receptor gamma in the pancreas, aiming to reveal its effects on metabolism.
Details 詳細情報について
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- CRID
- 1040000782006635776
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- Text Lang
- ja
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- Data Source
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- KAKEN