Comprehensive functional analysis of CNS border associted macrophages in brain development

KAKEN

About This Project

Japan Grant Number
JP25H01009 (JGN)
Funding Program
Grants-in-Aid for Scientific Research
Funding Organization
Japan Society for the Promotion of Science

Kakenhi Information

Project/Area Number
25H01009
Research Category
Grant-in-Aid for Scientific Research (A)
Allocation Type
  • Single-year Grants
Review Section / Research Field
  • Medium-sized Section 46:Neuroscience and related fields
Research Institution
  • Kyushu University
Project Period (FY)
2025-04-01 〜 2029-03-31
Project Status
Granted
Budget Amount*help
46,150,000 Yen (Direct Cost: 35,500,000 Yen Indirect Cost: 10,650,000 Yen)

Research Abstract

髄膜や血管周囲スペースといった脳の実質と末梢の境界領域には、脳境界マクロファージ（CAMs)という脳内マクロファージが存在する。本研究では、独自開発したCAMs特異的細胞機能操作ツールや非侵襲的イメージング、高深度1細胞マルチオミクス解析や高次ネットワーク機能解析など最先端の解析技術を駆使して、正常脳形成におけるCAMsの役割およびその破綻がもたらす脳形成異常と疾患発症メカニズムの解明に取り組む。

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