Development of anti-cancer agents targeting R-spondin-LGR4/5/6-ZNRF3/RNF43 axis
About This Project
- Japan Grant Number
- JP15H04806 (JGN)
- Funding Program
- Grants-in-Aid for Scientific Research
- Funding Organization
- Japan Society for the Promotion of Science
Kakenhi Information
- Project/Area Number
- 15H04806
- Research Category
- Grant-in-Aid for Scientific Research (B)
- Allocation Type
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- Single-year Grants
- Review Section / Research Field
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- Biological Sciences > Medicine, Dentistry, and Pharmacy > Clinical internal medicine > Gastroenterology
- Research Institution
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- The University of Tokyo
- Project Period (FY)
- 2015-04-01 〜 2018-03-31
- Project Status
- Completed
- Budget Amount*help
- 17,680,000 Yen (Direct Cost: 13,600,000 Yen Indirect Cost: 4,080,000 Yen)
Research Abstract
Utilizing a novel assay system targeting R-spondin-LGR4/5/6-ZNRF3/RNF43 axis, we first screened a small-molecule compound library to elucidate the R-spondin inhibitors as the anti-cancer agents and the R-spondin substitutes as the stimulating factors of intestinal stem cells. As the results, 60 compounds for inhibitor and one compound for stimulator became the candidates. As the succeeding analysis, the stimulator was confirmed to act through R-spondin-LGR4/5/6-ZNRF3/RNF43 axis, which indicated that the compound would be a promising seed of agents in the field of gastrointestinal regenerative medicine.
Keywords
Details 詳細情報について
-
- CRID
- 1040282256808514688
-
- Text Lang
- ja
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- Data Source
-
- KAKEN
