Clarifying the underlying pathophysiology of neuropsychiatric disorders using human-tissues-directly-derived neuronal/glial cells: Reverse-Translational Study.

KAKEN

About This Project

Japan Grant Number
JP18H04042 (JGN)
Funding Program
Grants-in-Aid for Scientific Research
Funding Organization
Japan Society for the Promotion of Science

Kakenhi Information

Project/Area Number
18H04042
Research Category
Grant-in-Aid for Scientific Research (A)
Allocation Type
  • Single-year Grants
Review Section / Research Field
  • Medium-sized Section 52:General internal medicine and related fields
Research Institution
  • Kyushu University
Project Period (FY)
2018-04-01 〜 2022-03-31
Project Status
Completed
Budget Amount*help
44,200,000 Yen (Direct Cost: 34,000,000 Yen Indirect Cost: 10,200,000 Yen)

Research Abstract

In this study, human iMG and iN cells were generated as disease model cells from patients with various neuropsychiatric disorders. Human iN cells and iMG cells were used to measure items that can only be assessed in living cells, and correlation analysis with clinical symptoms was conducted to detect disease specificity and elucidate pathophysiology at the dynamic cellular level. Specific characteristics were found in iN and iMG cells derived from patients with developmental disorders and dementia-related diseases. Furthermore, we found that human blood-derived iMG cells resemble human brain microglial cells, and revealed the usefulness of iMG cells as surrogate cells for reverse-translational research.

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