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Development of novel treatment strategies based on elucidation of the mechanisms of complex regional pain syndrome (CRPS)
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- Shibata Shiho
- Principal Investigator
- 福岡大学
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- 田頭 秀章
- Co-Investigator
- 福岡大学
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- 鈴木 沙理
- Co-Investigator
- 福岡大学
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- 山浦 健
- Co-Investigator
- 九州大学
About This Project
- Japan Grant Number
- JP18K08837 (JGN)
- Funding Program
- Grants-in-Aid for Scientific Research
- Funding Organization
- Japan Society for the Promotion of Science
Kakenhi Information
- Project/Area Number
- 18K08837
- Research Category
- Grant-in-Aid for Scientific Research (C)
- Allocation Type
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- Multi-year Fund
- Review Section / Research Field
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- Basic Section 55050:Anesthesiology-related
- Research Institution
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- Fukuoka University
- Project Period (FY)
- 2018-04-01 〜 2023-03-31
- Project Status
- Completed
- Budget Amount*help
- 4,420,000 Yen (Direct Cost: 3,400,000 Yen Indirect Cost: 1,020,000 Yen)
Research Abstract
Complex regional pain syndrome (CRPS) is an intractable chronic pain syndrome with various signs and symptoms including allodynia/hyperalgesia, edema, swelling, and skin abnormalities. However, a definitive therapeutic treatment for CRPS has not been established. In CRPS patients, inflammatory cytokines such as TNF-α and IL-1β have been shown to increase in affected areas, suggesting that these molecules may be potential therapeutic targets for CRPS. In this study, we found that the abnormal expression changes of Na+/Ca2+ exchanger (NCX) and Na+,K+-ATPase (NKA), and the abnormal activity of inflammation-related cells (macrophages and microglia).
Keywords
Details 詳細情報について
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- CRID
- 1040282256977659904
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- Text Lang
- ja
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- Data Source
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- KAKEN