Overview of the regulation of skeletal muscle metabolism based on comprehensive molecular quantification

KAKEN

About This Project

Japan Grant Number
JP18K15011 (JGN)
Funding Program
Grants-in-Aid for Scientific Research
Funding Organization
Japan Society for the Promotion of Science

Kakenhi Information

Project/Area Number
18K15011
Research Category
Grant-in-Aid for Early-Career Scientists
Allocation Type
  • Multi-year Fund
Review Section / Research Field
  • Basic Section 48020:Physiology-related
Research Institution
  • Kyushu University
Project Period (FY)
2018-04-01 〜 2023-03-31
Project Status
Completed
Budget Amount*help
4,160,000 Yen (Direct Cost: 3,200,000 Yen Indirect Cost: 960,000 Yen)

Research Abstract

In this project, skeletal muscle composition was analyzed in terms of molecular concentration/proportion, and their temporal variation over four hours after insulin administration. A molecular interaction network consisting of approximately 10,000 insulin-responsive molecules (nodes) was constructed based on this analysis. This network illustrates about 20,000 interactions (edges) among metabolites, RNAs, and proteins that changed in their phosphorylation or expression levels. Such a comprehensive analysis provided an overview of major regulatory processes within skeletal muscles in response to insulin. Our investigation model enabled the design of scalable methods that could integrate multiple sources to characterize and visualize biologically relevant molecular interactions.

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