6,370,000 Yen
(Direct Cost: 4,900,000 Yen Indirect Cost: 1,470,000 Yen)
Research Abstract
Polyethylene terephthalate has been used as an artificial tendon and an artificial ligament. However, polyethylene terephthalate has no bone-bonding ability. In this study, we tried to give a function of bone bonding to polyethylene terephthalate to change the surface properties of polyethylene terephthalate.
In this study, we prepared two types of polyethylene terephthalate, surface hydrolyzed polyethylene terephthalate and phosphate modified polyethylene terephthalate. Compared with non-treated polyethylene terephthalate, surface treated polyethylene terephthalate improved the osteoblast activity and bone bonding ability in vivo experiment. Thus, we reveal that the surface treatment could give a bone bonding ability to polyethylene terephthalate.
