Role of a new member of the NLR family in pathogen recognition and shaping adaptive immunity
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- KAWAI Taro
- Principal Investigator
- Osaka University
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- KUMAR Himanshu
- Research Collaborator
- 大阪大学
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- TSUCHIDA Tetsuo
- Research Collaborator
- 大阪大学
About This Project
- Japan Grant Number
- JP21790386 (JGN)
- Funding Program
- Grants-in-Aid for Scientific Research
- Funding Organization
- Japan Society for the Promotion of Science
Kakenhi Information
- Project/Area Number
- 21790386
- Research Category
- Grant-in-Aid for Young Scientists (B)
- Allocation Type
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- Single-year Grants
- Review Section / Research Field
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- Biological Sciences > Medicine, Dentistry, and Pharmacy > Basic medicine > Experimental pathology
- Research Institution
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- Osaka University
- Project Period (FY)
- 2009 〜 2010
- Project Status
- Completed
- Budget Amount*help
- 4,290,000 Yen (Direct Cost: 3,300,000 Yen Indirect Cost: 990,000 Yen)
Research Abstract
We analyzed roles of NLR-tb, a new member of the NLR family that we identified, in the regulation of innate immunity. We found that NLR-tb is capable of inducing the production of inflammatory cytokine IL-1beta. Furthermore, our analyses on NLR-tb-deficient mice suggested the possibility that NLR-tb responds to unknown pathogen components.
