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Regulation cell function by light using LOV photoreceptive module
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- TOKUTOMI Satoru
- Principal Investigator
- 大阪府立大学
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- IHARA Hideshi
- Research Partners
- 大阪府立大学
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- OKAJIMA Koji
- Research Partners
- 大阪府立大学
About This Project
- Japan Grant Number
- JP23657105 (JGN)
- Funding Program
- Grants-in-Aid for Scientific Research
- Funding Organization
- Japan Society for the Promotion of Science
Kakenhi Information
- Project/Area Number
- 23657105
- Research Category
- Grant-in-Aid for Challenging Exploratory Research
- Allocation Type
-
- Multi-year Fund
- Review Section / Research Field
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- Biological Sciences > Biology > Biological science > Biophysics
- Research Institution
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- Osaka Prefecture University
- Project Period (FY)
- 2011 〜 2012
- Project Status
- Completed
- Budget Amount*help
- 3,770,000 Yen (Direct Cost: 2,900,000 Yen Indirect Cost: 870,000 Yen)
Research Abstract
Phototropin is a blue light sensor in plant which mediates phototropic response et al., and act as a blue light regulated protein kinase. Using the photoactivation mechanism of kinase in the phototropin, we aim to produce a new animal cell of which physiological responses, cell division and cell differentiation, can be switchable by light illumination through controlling the kinase activity of the key protein kinase involved. We introduced the in vitro analysis system in which the regulation of the key enzyme activity can be studied.