Development and mechanism of action of rare sugar derivatives with antiproliferative effect
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- YANAGITA Ryo
- Principal Investigator
- 香川大学
About this project
- Japan Grant Number
- JP23780117
- Funding Program
- Grants-in-Aid for Scientific Research
- Funding organization
- Japan Society for the Promotion of Science
- Project/Area Number
- 23780117
- Research Category
- Grant-in-Aid for Young Scientists (B)
- Allocation Type
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- Multi-year Fund
- Review Section / Research Field
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- Biological Sciences > Agriculture > Agricultural chemistry > Bioproduction chemistry/Bioorganic chemistry
- Research Institution
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- Kagawa University
- Project Period (FY)
- 2011 〜 2013
- Project Status
- Completed
- Budget Amount*help
- 4,420,000 Yen (Direct Cost: 3,400,000 Yen Indirect Cost: 1,020,000 Yen)
Research Abstract
The objectives of this project is to develop superior derivatives of D-allose, a rare sugar showing antiproliferative effect against human cancer cell lines, and molecular probes for an analysis of its mechanism of action. First, we examined the modification for the C-6 OH group of D-allose and found that D-allose C-6 ester with medium chain fatty acids showed about 30 times higher effect compared to D-allose against human leukemia MOLT-4F cell line. Then, we evaluated the activity of D-allose derivatives with 5-membered furanose form, and found that 6-membered pyranose form might be important for the activity of D-allose esters. Finally, we synthesized cell-permeable prodrugs for monosaccharide 6-phosphate, which could be a lead for molecular probes for an analysis of the mechanism of action.
Details 詳細情報について
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- CRID
- 1040282257161014272
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- Text Lang
- ja
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- Data Source
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- KAKEN
