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Evolutionary developmental analysis for the origin and migration of primordial germ cells
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- Kusakabe Rie
- Principal Investigator
- 国立研究開発法人理化学研究所
-
- INOUE Kunio
- Research Collaborator
- 神戸大学
About This Project
- Japan Grant Number
- JP25440108 (JGN)
- Funding Program
- Grants-in-Aid for Scientific Research
- Funding Organization
- Japan Society for the Promotion of Science
Kakenhi Information
- Project/Area Number
- 25440108
- Research Category
- Grant-in-Aid for Scientific Research (C)
- Allocation Type
-
- Multi-year Fund
- Review Section / Research Field
-
- Biological Sciences > Biology > Biological science > Developmental biology
- Research Institution
-
- Institute of Physical and Chemical Research
- Kobe University
- Project Period (FY)
- 2013-04-01 〜 2017-03-31
- Project Status
- Completed
- Budget Amount*help
- 5,330,000 Yen (Direct Cost: 4,100,000 Yen Indirect Cost: 1,230,000 Yen)
Research Abstract
The cyclostome lampreys, a group of vertebrates that diverged early in evolution, retain various ancestral morphological features. In order to clarify the evolutionary pathway of origin and developmental behavior of undifferentiated precursor cells, including primordial germ cells, we conducted examination of expression patterns of developmental genes and histological observation. We also attempted the new experimental techniques for lineage tracing after introduction of artificial gene constructs. Comparison with insights from other vertebrate species implied the evolutionary relationships of the migratory undifferentiated precursor cells and the establishment of complex and diverse morphology of vertebrates.
