PML-RARA of the short but long isoform initiate from TIM-3+ leukemic stem cells with hierarchical leukemic organization

KAKEN

About This Project

Japan Grant Number
JP22K19544 (JGN)
Funding Program
Grants-in-Aid for Scientific Research
Funding Organization
Japan Society for the Promotion of Science

Kakenhi Information

Project/Area Number
22K19544
Research Category
Grant-in-Aid for Challenging Research (Exploratory)
Allocation Type
  • Multi-year Fund
Review Section / Research Field
  • Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
Research Institution
  • Kanazawa University
Project Period (FY)
2022-06-30 〜 2024-03-31
Project Status
Completed
Budget Amount*help
6,500,000 Yen (Direct Cost: 5,000,000 Yen Indirect Cost: 1,500,000 Yen)

Research Abstract

未だ白血病幹細胞の存在が否定的なAPLにおいて、我々が同定した白血病幹細胞機能分子TIM-3を指標として幹細胞集団を細分画することで、APL幹細胞の存在を実証する。さらにAPL特異的PML-RARA遺伝子は染色体転座切断部位により２つに大別されshort typeとlong typeにおいて異なる白血化機構を解明し、より有効な標的治療を開発する。

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