Mechanism of transcription coupled to RNA processing and its defect

KAKEN

About This Project

Japan Grant Number
JP19K24692 (JGN)
Funding Program
Grants-in-Aid for Scientific Research
Funding Organization
Japan Society for the Promotion of Science

Kakenhi Information

Project/Area Number
19K24692
Research Category
Fund for the Promotion of Joint International Research (Home-Returning Researcher Development Research)
Allocation Type
  • Multi-year Fund
Review Section / Research Field
  • Biological Sciences
Research Institution
  • Kyushu University
Project Period (FY)
2021-03-12 〜 2024-03-31
Project Status
Completed
Budget Amount*help
55,770,000 Yen (Direct Cost: 42,900,000 Yen Indirect Cost: 12,870,000 Yen)

Research Abstract

This research aimed to understand a gene transcription and its coupled RNA processing, which are important regulatory steps in eukaryotic gene expression, and to develop necessary analytical methods and gain medical insights. Firstly, we successfully established the POINT method, which allows analysis of newly transcribed RNA. My POINT method reveals precise transcription start sites, RNA cleavage sites, and kinetics of co-transcriptional splicing. We also demonstrates the importance of alternative splicing during developmental stages. Additionally, the mechanisms of transcription termination defect in colorectal cancer and kidney cancer are revealed. The findings of this research contribute to the advancement of basic biology and also the development of treatment methods for diseases such as cancer.

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