Elucidation of the factors controlling genome modality in the determination of inactive X chromosome

About this project

Japan Grant Number
JP21H05753
Funding Program
Grants-in-Aid for Scientific Research
Funding organization
Japan Society for the Promotion of Science
Project/Area Number
21H05753
Research Category
Grant-in-Aid for Transformative Research Areas (A)
Allocation Type
  • Single-year Grants
Review Section / Research Field
  • Transformative Research Areas, Section (III)
Research Institution
  • Hiroshima University
Project Period (FY)
2021-09-10 〜 2023-03-31
Project Status
Completed
Budget Amount*help
13,000,000 Yen (Direct Cost: 10,000,000 Yen Indirect Cost: 3,000,000 Yen)

Research Abstract

メスの哺乳類細胞では、発生初期に2本のX染色体のうちの1本がランダムに不活性化されるが、不活性化X染色体決定機構は明らかになっていない。本研究では、X染色体不活性化を誘導できるメスマウス胚性幹(ES)細胞を用いて、高次ゲノム構造等のDNAの構造的側面と転写などのDNAの情報的側面を経時的に定量し、不活性化X染色体決定制御機構の解明を目指す。

Related Articles

See more

Related Data

See more

Related Books

See more

Related Dissertations

See more

Related Projects

See more

Related Products

See more

Details 詳細情報について

Back to top