Elucidation of essential common molecular mechanisms that control postmenopausal osteoporosis and weight gain and development of therapeutic strategies

KAKEN

About This Project

Japan Grant Number
JP21H03108 (JGN)
Funding Program
Grants-in-Aid for Scientific Research
Funding Organization
Japan Society for the Promotion of Science

Kakenhi Information

Project/Area Number
21H03108
Research Category
Grant-in-Aid for Scientific Research (B)
Allocation Type
  • Single-year Grants
Review Section / Research Field
  • Basic Section 57010:Oral biological science-related
Research Institution
  • Kyushu University
Project Period (FY)
2021-04-01 〜 2024-03-31
Project Status
Completed
Budget Amount*help
17,290,000 Yen (Direct Cost: 13,300,000 Yen Indirect Cost: 3,990,000 Yen)

Research Abstract

高齢女性の閉経は、女性ホルモンの減少による骨量の減少と体重増加を起こす。最近、女性ホルモンの一種であるエストロンE1が、NF-κBシグナルと協調して炎症を亢進させる現象が報告されたことから、1）女性ホルモンによる骨代謝とエネルギー代謝に共通の制御機構の解析、2）卵巣摘出における女性ホルモンとNF-κB間のクロストーク解析、3）骨量減少と体重増加を抑制する薬剤の探索を行う。

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