Elucidation of novel regulatory mechanism of bone metabolism by epithelial cells

About this project

Japan Grant Number
JP23K18363
Funding Program
Grants-in-Aid for Scientific Research
Funding organization
Japan Society for the Promotion of Science
Project/Area Number
23K18363
Research Category
Grant-in-Aid for Challenging Research (Exploratory)
Allocation Type
  • Multi-year Fund
Review Section / Research Field
  • Medium-sized Section 57:Oral science and related fields
Research Institution
  • Kyushu University
Project Period (FY)
2023-06-30 〜 2025-03-31
Project Status
Granted
Budget Amount*help
6,500,000 Yen (Direct Cost: 5,000,000 Yen Indirect Cost: 1,500,000 Yen)

Research Abstract

本研究では、我々の海綿骨が著しく増加した上皮系細胞特異的p130Cas欠損マウスを用いて、これまで知られていない上皮系細胞によるp130Casを介した骨形成抑制機構に着目し、この責任細胞や分子機序を明らかにし、新しい骨代謝制御機構を解明するだけでなく、骨粗鬆症などの骨代謝疾患の治療へ展開する。

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