〔研究ノート〕卵巣摘除された慢性腎臓病モデルラットの骨代謝維持に 対する食餌アルギニンあるいは大豆イソフラボン抽出物 投与の有効性評価に関する基礎的研究

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  • A Basic Study of the Efficacy of the Dietary L-Arginine and Soy Isoflavone-Extracted on the Bone Metabolism in Ovariectomized Chronic Kidney Disease（CKD）Model Rats
  • ランソウテキジョサレタ マンセイ ジンゾウビョウ モデルラット ノ ホネ タイシャ イジ ニ タイスル ショクジ アルギニン アルイハ ダイズ イソフラボン チュウシュツブツ トウヨ ノ ユウコウセイ ヒョウカ ニ カンスル キソテキ ケンキュウ

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The present study was carried out to elucidate the protective effects of dietary L-arginine and soy isoflavone-extracted on the bone metabolism in the ovariectomized chronic kidney disease model rats. 　　Nine-week-old female rats received 360mg/kg BW of adenine intragastrally for four consecutive days so that they would develop chronic kidney disease（CKD）. After six days of recovery, rats received ovariectomies（OVX）under anesthesia. A sham operation was carried out on another group of rats（group Intact）. 　　Seven days after the OVX, the rats were given either a control diet（20％ casein protein diet（group CA）; 0.5％ L-arginine supplemented diet（group Arg）; or 0.20％ soy isoflavone-extracted supplemented diet（group IF）, 13g per day for 12 weeks. Rats in group Intact were, like group CA, given the control diet. 　　The results were as follows: 1）Group CA developed moderate chronic kidney disease which was manifested as elevated kidney weight, increased serum creatinine, relatively lower creatinine clearance and reduced femoral-BMD than that of group Intact. 2）The L-Arginine supplemented diet did not improve renal function and femoral BMD-loss. But, increased mRNA expression levels of IGF-1, BMP-2 and Osterix were observed in the femurs. 3）Soy isoflavone-extracted supplemented diet had no preventative effects on BMD loss, although estrogen receptor-beta mRNA expression levels in the femurs were elevated. 　　From these results, bone-protective functions of L-arginine via activation of osteoblast differentiation and bone formation process were suggested. Further investigation to clarify the efficacy of L-arginine-IGF-1 signal transduction on the bone metabolism is required to determine whether a therapy based on this approach can help people suffering from osteoporosis in CKD patients.

収録刊行物

  • 学苑

    学苑 (914), ６-14, 2016-12-01

    昭和女子大学近代文化研究所

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