Bibliographic Information
- Other Title
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- ショウジョウバエにおける抗菌ペプチドの分子進化
- ショウジョウバエ ニ オケル コウキン ペプチド ノ ブンシ シンカ
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Description
Antimicrobial peptides (AMPs) are essential components for Drosophila innate immune systems against microorganisms. Seven antimicrobial peptides have been identified in D. melanogaster, in which some AMPs show strong anti-bacterial activity, but others show anti-fungal activity. Repertoire of AMPs and their expression patterns are important for individual fly to survive under infection of Gram-negative, Gram-positive bacteria and fungi. Many molecular evolutionary analyses show different AMP genes have evolved in different manner. Cecropin and Drosomycin genes, for example, have evolved under frequent gene duplication and deletion event, so-called birth-and-death evolution, while Metchnikwin and Drosocin genes have kept only one copy in their host genome through Drosophila evolution. Ecologically, Drosophila is distributed among various environments from Tropical to Polar Zone, and some species have more resistance to bacteria or fungi than others have. However, the molecular-based mechanisms which affect a resistance to microorganisms still have not been elucidated clearly. In this paper, we introduce functions of Drosophila AMPs and their molecular evolution, and then discuss evolutionary relationship between them.
Journal
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- Low Temperature Science
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Low Temperature Science 69 157-163, 2011-03-31
北海道大学低温科学研究所
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Details 詳細情報について
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- CRID
- 1050001339008159872
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- NII Article ID
- 40018938278
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- NII Book ID
- AA12122962
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- HANDLE
- 2115/45200
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- NDL BIB ID
- 11195747
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- ISSN
- 18807593
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- Text Lang
- ja
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- Article Type
- departmental bulletin paper
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- Data Source
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- IRDB
- NDL
- CiNii Articles