骨の機械応答とosteocyte

IR

Bibliographic Information

Other Title
  • Osteocytes in the skeletal response to weightlessness

Description

Bone metabolism is performed by bone-degrading osteoclasts and bone-building osteoblasts on bone surface. The osteocyte is a third cell type in bone that is derived from osteoblast lineage cells and embedded in the mineralized matrix. In order to delineate the in vivo function of the osteocyte, we have developed a transgenic mouse model that enables targeted ablation of osteocytes following a single injection of diphtheria toxin. Under normal loading condition, ablation of osteocytes caused aberrant activation of osteoclastic bone resorption with elevated expression of RANKL (Receptor Activator of NF-KB Ligand). In contrast, during unloading by tail suspension, the osteocyte-depleted mice were protected from disuse-induced bone atrophy. These data suggest that osteocytes play a pivotal role in sensing and/or transducing mechanical signals to adapt the structure and function of bone according to changing mechanical environments.

資料番号: AA0063706060

Journal

Keywords

Details 詳細情報について

  • CRID
    1050011086241573760
  • NII Article ID
    120006830680
  • Web Site
    http://id.nii.ac.jp/1696/00013430/
  • Text Lang
    ja
  • Article Type
    conference paper
  • Data Source
    • IRDB
    • CiNii Articles

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