骨の機械応答とosteocyte
書誌事項
- タイトル別名
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- Osteocytes in the skeletal response to weightlessness
説明
Bone metabolism is performed by bone-degrading osteoclasts and bone-building osteoblasts on bone surface. The osteocyte is a third cell type in bone that is derived from osteoblast lineage cells and embedded in the mineralized matrix. In order to delineate the in vivo function of the osteocyte, we have developed a transgenic mouse model that enables targeted ablation of osteocytes following a single injection of diphtheria toxin. Under normal loading condition, ablation of osteocytes caused aberrant activation of osteoclastic bone resorption with elevated expression of RANKL (Receptor Activator of NF-KB Ligand). In contrast, during unloading by tail suspension, the osteocyte-depleted mice were protected from disuse-induced bone atrophy. These data suggest that osteocytes play a pivotal role in sensing and/or transducing mechanical signals to adapt the structure and function of bone according to changing mechanical environments.
資料番号: AA0063706060
収録刊行物
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- 宇宙利用シンポジウム 第24回 平成19年度 = Space Utilization Research: Proceedings of the Twenty-fourth Space Utilization Symposium
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宇宙利用シンポジウム 第24回 平成19年度 = Space Utilization Research: Proceedings of the Twenty-fourth Space Utilization Symposium 234-235, 2008-03
宇宙航空研究開発機構宇宙科学研究本部
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詳細情報 詳細情報について
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- CRID
- 1050011086241573760
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- NII論文ID
- 120006830680
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- Web Site
- http://id.nii.ac.jp/1696/00013430/
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- 本文言語コード
- ja
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- 資料種別
- conference paper
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- データソース種別
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- IRDB
- CiNii Articles