The phosphorylated pathway of serine biosynthesis affects sperm, embryo, and sporophyte development, and metabolism in Marchantia polymorpha
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- ワン, ムンヤオ
- RIKEN Center for Sustainable Resource Science; Graduate School of Bioagricultural Sciences, Nagoya University
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- 多部田, 弘光
- RIKEN Center for Sustainable Resource Science; Graduate School of Arts and Sciences, The University of Tokyo; Department of Biology, Tokyo Gakugei University
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- 大髙, きぬ香
- RIKEN Center for Sustainable Resource Science; Graduate School of Bioagricultural Sciences, Nagoya University; Present address: Department of Chemical and Biological Sciences, Japan Women’s University
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- 桑原, 亜由子
- RIKEN Center for Sustainable Resource Science
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- 西浜, 竜一
- Graduate School of Biostudies, Kyoto University; Present address: Department of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Science
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- 石川, 寿樹
- Graduate School of Science and Engineering, Saitama University
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- 豊岡, 公徳
- RIKEN Center for Sustainable Resource Science
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- 佐藤, 繭子
- RIKEN Center for Sustainable Resource Science
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- 若崎, 眞由美
- RIKEN Center for Sustainable Resource Science
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- 明石, 寛道
- RIKEN Center for Sustainable Resource Science
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- 津川, 裕司
- RIKEN Center for Sustainable Resource Science; Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology
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- 庄司, 翼
- RIKEN Center for Sustainable Resource Science
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- 岡咲, 洋三
- RIKEN Center for Sustainable Resource Science; Graduate School of Bioresource, Mie University
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- 吉田, 啓亮
- Institute of Innovative Research, Tokyo Institute of Technology
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- 佐藤, 諒一
- RIKEN Center for Sustainable Resource Science
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- フェルジャニ, アリ
- Department of Biology, Tokyo Gakugei University
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- 河内, 孝之
- Graduate School of Biostudies, Kyoto University
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- 平井, 優美
- RIKEN Center for Sustainable Resource Science; Graduate School of Bioagricultural Sciences, Nagoya University
抄録
Serine metabolism is involved in various biological processes. Here we investigate primary functions of the phosphorylated pathway of serine biosynthesis in a non-vascular plant Marchantia polymorpha by analyzing knockout mutants of MpPGDH encoding 3-phosphoglycerate dehydrogenase in this pathway. Growth phenotypes indicate that serine from the phosphorylated pathway in the dark is crucial for thallus growth. Sperm development requires serine from the phosphorylated pathway, while egg formation does not. Functional MpPGDH in the maternal genome is necessary for embryo and sporophyte development. Under high CO2 where the glycolate pathway of serine biosynthesis is inhibited, suppressed thallus growth of the mutants is not fully recovered by exogenously-supplemented serine, suggesting the importance of serine homeostasis involving the phosphorylated and glycolate pathways. Metabolomic phenotypes indicate that the phosphorylated pathway mainly influences the tricarboxylic acid cycle, the amino acid and nucleotide metabolism, and lipid metabolism. These results indicate the importance of the phosphorylated pathway of serine biosynthesis in the dark, in the development of sperm, embryo, and sporophyte, and metabolism in M. polymorpha.
収録刊行物
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- Communications Biology
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Communications Biology 7 2024-01-24
Springer Nature
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詳細情報 詳細情報について
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- CRID
- 1050017500391720576
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- ISSN
- 23993642
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- HANDLE
- 2433/286779
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- IRDB