Host-Guest Interaction-Controlled Site-selective C–H Borylation of Aromatic Compounds

IR (HANDLE) Open Access
  • Su, Haotian
    Department of Interdisciplinary Engineering Sciences, Interdisciplinary Graduate School of Engineering Sciences, Kyushu University
  • Kuninobu, Yoichiro
    Institute for Materials Chemistry and Engineering, Kyushu University Department of Interdisciplinary Engineering Sciences, Interdisciplinary Graduate School of Engineering Sciences, Kyushu University

Description

The site-selective transformation of aromatic compounds remains a challenge in organic synthesis. Conventional methods for controlling site-selectivity often use directing groups, which limit substrate availability owing to the need for coordinating functional groups. Herein, we report a strategy in which the cyclic moiety of a catalyst recognizes and traps the substrate via host-guest interaction between the catalyst and substrate, allowing the catalytically active site to preferentially approach the desired reaction site, thereby enabling site-selective reactions. This catalyst can be used to control the site-selectivity of substrates that lack functional groups, which are essential in conventional methods. These results have the potential to extend the substrate scope and provide new catalyst designs for carbon–hydrogen bond transformations.

Journal

  • ChemRxiv

    ChemRxiv 2025-03-14

    Cambridge University Press

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Keywords

Details 詳細情報について

  • CRID
    1050022457824840704
  • ISSN
    25732293
  • HANDLE
    2324/7347379
  • Text Lang
    en
  • Article Type
    journal article
  • Data Source
    • IRDB

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