蓚酸代謝関連酵素に尿路結石治療の未来を求めて (第59回日本泌尿器科学会中部総会)

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タイトル別名
  • Future Perspective in the Treatment of Urolithiasis Based on Oxalate Metabolism
  • 蓚酸代謝関連酵素に尿路結石治療の未来を求めて
  • シュウサン タイシャ カンレン コウソ ニ ニョウロ ケッセキ チリョウ ノ ミライ オ モトメテ

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抄録

Urinary excretion of oxalate is one of risk factors in urinary stone formation. Prevention of undesirable overflow into the production of oxalate definitely leads to a decrease of urolithiasis. The activity of serine : pyruvate/alanine : glyoxylate aminotransferase (SPT/AGT) or glyoxylate reductase/hydroxypyruvate reductase (GRHPR), the key enzyme of primary hyperoxlauria type 1 and 2, respectively, and their subcellular distribution highly affects theoxalateproduction. On theothe r hand, urolithiasis is tightly related to lifestyle disease, such as diabetes mellitus and insulin resistance. The hypothesis that insulin resistance induces mitochondria dysfunction, resulting in the decrease of mitochondria-related enzyme activity is a very attractive new treatment strategy of urolithiasis. Namely, the improvement of insulin resistance might prevent stone formation.

収録刊行物

  • 泌尿器科紀要

    泌尿器科紀要 57 (1), 39-41, 2011-01

    泌尿器科紀要刊行会

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