End joining activity of DNA double-strand breaks in the embryonic mouse brain

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Abstract

Double-strand breaks (DSBs) of DNA are introduced in neurons during embryonic brain development. Here I examine the DNA end joining activity to restore DSBs bearing distinct types of DNA ends in embryonic and adult brains. Embryonic brains contained the end joining activity for cohesive DNA ends. By contrast, adult brains showed no detectable end joining activity. The degree of the end joining activity seemed to be correlated with viability of neurons in culture. Thus, DNA repair for DSBs is likely to be involved in neuronal viability during brain development.

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