Multidrug resistance reversal by 3-formylchromones in human colon cancer and human mdr1 gene-transfected mouse lymphoma cells
書誌事項
- 公開日
- 2006-09
- 資源種別
- journal article
- 公開者
- International Institute of Anticancer Research
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説明
type:text
Several new 3-formylchromone derivatives proved to be modifiers of multidrug resistance in mouse lymphoma cells and in human Colo320 colon cancer cells. There is apparently a structure-activity relationship between the antiproliferative multidrug resistance-reversing effect and the chemical structure of the 3-formylchromones. The total polar surface areas and the ground state dipole moments of the molecules are presumed to play a key role in the multidrug resistance-reversing effect. The log P values can provide an adequate explanation for the selective cytotoxicity against cancer cells.
5p.
identifier:JOS-0258851X-20-645
収録刊行物
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- In Vivo : International Journal of Experimental and Clinical Pathophysiology of Drug Research
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In Vivo : International Journal of Experimental and Clinical Pathophysiology of Drug Research 20 (5), 645-649, 2006-09
International Institute of Anticancer Research
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詳細情報 詳細情報について
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- CRID
- 1050282677762982016
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- NII論文ID
- 120005518450
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- NII書誌ID
- AA10714348
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- ISSN
- 0258851X
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- IRDB
- CiNii Articles
