嗅球摘出マウスの認知障害に対するフルボキサミンの改善作用

機関リポジトリ Web Site

書誌事項

タイトル別名
  • Fluvoxamine ameliorates cognitive dysfunctions in olfactory bulbectomized mice
  • キュウキュウ テキシュツ マウス ノ ニンチ ショウガイ ニ タイスル フルボキサミン ノ カイゼン サヨウ

この論文をさがす

説明

This study was undertaken to examine the effect of the selective serotonin reuptake inhibitor（ssRi）fluvoxamine on cognitive dysfunctions in olfactory bulbectomized（OBX）mice. in the novel object recognition test, OBX mice significantly decreased the exploratory preference in the retention session, but not in the training session. OBX-induced cognitive dysfunctions were significantly improved by chronic（3-week）administration of fluvoxamine（30 mg/kg/day）, but not acute. The present study suggests that chronic fluvoxamine treatment may ameliorate OBX-induced cognitive dysfunctions via a mechanism involving enhancement of synaptic plasticityrelated signaling. Therefore, ssRi such as fluvoxamine would be potential therapeutic drugs for the treatment of the cognitive dysfunctions of alzheimer s disease.

収録刊行物

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ