マウスにおける 2,5,2', 5'-Tetrachlorobiphenyl の代謝に及ぼすフェノバルビタールの影響(B. 生活科学)

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  • マウスにおける2,5,2′,5′-Tetrachlorobiphenylの代謝に及ぼすフェノバルビタールの影響
  • マウス ニ オケル 2 5 2 5 Tetrachlorobiphenyl ノ
  • Effects of Phenobarbital on the Metabolism of 2,5,2′, 5′-Tetrachlorobiphenyl in Mice (B. LIVING SCIENCE)

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Effects of phenobarbital (PB), a potent inducer of microsomal drug-metabolizing enzymes, on the levels of metabolites of 2,5,2', 5'-tetrachlorobiphenyl (TCB) were studied in mice. Pretreatment of mice with PB (100mg/day/kg body weight) for 3 days before administration of a single dose of 2,5,2', 5'-TCB (8mg/mouse) resulted in 40 and 60% decreases of unchanged TCB in feces and whole-body tissues, respectively. The fecal extretion of methylthio-2,5,2', 5'-TCB's, which did not show any accumulation in tissues, was increased about 3 times the control value, whereas no alteration of the levels of methylsulfonyl-2,5,2', 5'-TCB's were observed in both feces and tissues. This marked increase in the level of methythio-TCB's is suggestive of the participation of microsomal drug-metabolizing enzymes in the formation of these metabolites. PB-pretreatment also resulted in a 40% increase in the fecal excretion of 3-hydroxy-2,5,2', 5'-TCB.

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