Direct observation of dynamic force propagation between focal adhesions of cells on microposts by atomic force microscopy
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説明
We investigated dynamic force propagation between focal adhesions of fibroblast cells cultured on polydimethylsiloxane micropost substrates, by atomic force microscopy. Live cells were mechanically modulated by the atomic force microscopy probe bound to cell apical surfaces at 0.01-0.5 Hz, while microposts served as a force sensor at basal surfaces. We observed that cells exhibited rheological behavior at the apical surface but had no apparent out-of-phase response at the basal surface, indicating that the dynamic force propagating through cytoskeletal filaments behaves in an elastic manner. Moreover, the direction of the propagated force was observed to be intimately associated with the prestress.
収録刊行物
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- Applied Physics Letters
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Applied Physics Letters 99 (26), 263703-, 2011-12-26
American Institute of Physics
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詳細情報 詳細情報について
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- CRID
- 1050282813987259392
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- NII論文ID
- 120003783352
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- ISSN
- 10773118
- 00036951
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- HANDLE
- 2115/48293
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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