膜型セリンプロテアーゼMT-SP1 によるCDCP1 切断を介した癌細胞の足場非依存性能の解析

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  • マクガタ セリンプロテアーゼ MT-SP1 ニ ヨル CDCP1 セツダン オ カイシタ ガン サイボウ ノ アシバ ヒイソン セイノウ ノ カイセキ
  • Analysis of the Anchorage-Independence of Cancer Cells　through CDCP1 Cleavage by Membrane-Type Serine Protease 1 (MT-SP1)

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CUB domain-containing protein 1 (CDCP1) is an important molecule for regulating　anchorage-independence involved in cancer metastasis. Recently, it was reported that the synthetic　substrate of CDCP1 is cleaved by Membrane-type serine protease 1(MT-SP1), however it is not clear that　this cleavage is involved in anchorage-independence. In this study, we investigated the effect of CDCP1　cleavage by MT-SP1 on anchorage-independence in cancer cells by soft agar assay using MT-SP1 siRNA　and uncleaved CDCP1 mutant (2RKAAres-F). As a result, cleavage of CDCP1 was inhibited in both　experiments, and then the anchorage independence was suppressed. Therefore, it is suggested that the　cleavage of CDCP1 by MT-SP1 is involved in the regulation of anchorage independence in cancer cells.

identifier:0385-7301

identifier:http://nda-repository.nda.ac.jp/dspace/handle/11605/139

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