Gene Duplication of Androgen Receptor As An Evolutionary Driving Force Underlying the Diversity of Sexual Characteristics in Teleost Fishes

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  • Ryu, Tsukasa
    Laboratory of Marine Biochemistry, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University
  • Okamoto, Keigo
    Laboratory of Aquatic Molecular Developmental Biology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University
  • Ansai, Satoshi
    Laboratory of Genome Editing Breeding, Graduate School of Agriculture, Kyoto University
  • Nakao, Miki
    Laboratory of Marine Biochemistry, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University Center for Promotion of International Education and Research, Faculty of Agriculture, Kyushu University
  • Kumar, Anu
    Commonwealth Scientific and Industrial Research Organization, CSIRO Environment
  • Iguchi, Taisen
    Graduate School of Nanobioscience, Yokohama City University Noto Marine Laboratory, Institute of Nature and Environmental Technology, Kanazawa University
  • Ogino, Yukiko
    Laboratory of Aquatic Molecular Developmental Biology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University Center for Promotion of International Education and Research, Faculty of Agriculture, Kyushu University

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Description

Sexual dimorphism allows species to meet their fitness optima based on the physiological availability of each sex. Although intralocus sexual conflict appears to be a genetic constraint for the evolution of sex-specific traits, sex-linked genes and the regulation of sex steroid hormones contribute to resolving this conflict by allowing sex-specific developments. Androgens and their receptor, androgen receptor (Ar), regulate male-biased phenotypes. In teleost fish, ar ohnologs have emerged as a result of teleost-specific whole genome duplication (TSGD). Recent studies have highlighted the evolutionary differentiation of ar ohnologs responsible for the development of sexual characteristics, which sheds light on the need for comparative studies on androgen regulation among different species. In this review, we discuss the importance of ar signaling as a regulator of male-specific traits in teleost species because teleost species are suitable experimental models for comparative studies owing to their great diversity in male-biased morphological and physiological traits. To date, both in vivo and in vitro studies on teleost ar ohnologs have shown a substantial influence of ars as a regulator of male-specific reproductive traits such as fin elongation, courtship behavior, and nuptial coloration. In addition to these sexual characteristics, ar substantially influences immunity, inducing a sex-biased immune response. This review aims to provide a comprehensive understanding of the current state of teleost ar studies and emphasizes the potential of teleost fishes, given their availability, to find molecular evidence about what gives rise to the spectacular diversity among fish species.

Journal

  • Zoological Science

    Zoological Science 41 (1), 68-76, 2024-02-14

    Zoological Society of Japan

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