抄録
Lamellarins are polycyclic marine alkaloids with potent cytotoxic activities against cancer cell lines. A divergent synthesis of azalamellarins D and N, lactam congeners of the marine natural products lamellarins D and N, has been achieved via the pentacyclic 14-bromo-8,9-dihydro-benzo[7,8]indolizino[3,2-c]- quinolin-6(5H)-one intermediate. The pentacyclic intermediate can be synthesized from methyl 1-(benzensulfonyl)-3-bromo-1H-pyrrole-2-carboxylate via the Suzuki–Miyaura cross-coupling and intramolecular direct arylation as key reactions.
Heterocycles, 103 (2), pp862-877; 2021
収録刊行物
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- HETEROCYCLES
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HETEROCYCLES 103 (2), 862-877, 2021-02-08
日本複素環化学研究所
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詳細情報 詳細情報について
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- CRID
- 1050854882675035520
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- ISSN
- 18810942
- 03855414
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- HANDLE
- 10069/00041475
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- IRDB
- Crossref
- KAKEN