Clarithromycin suppresses induction of monocyte chemoattractant protein-1 and matrix metalloproteinase-9 and improves pathological changes in the lungs and heart of mice infected with influenza A virus

書誌事項

タイトル
Clarithromycin suppresses induction of monocyte chemoattractant protein-1 and matrix metalloproteinase-9 and improves pathological changes in the lungs and heart of mice infected with influenza A virus
タイトル別名
  • クラリスロマイシンはインフルエンザAウイルスに感染したマウスにおいて、monocyte chemoattractant protein-1とmatrix metalloproteinase-9の発現誘導を抑制し、肺と心臓における病理学的変化を改善する
著者
高橋, 悦久
著者別名
  • タカハシ, エツヒサ
  • Takahashi, Etsuhisa
著者
Indalao, Irene L.
著者
サワブチ, タカコ
著者別名
  • Sawabuchi, Takako
著者
ミズノ, ケイコ
著者別名
  • Mizuno, Keiko
著者
サカイ, サトコ
著者別名
  • Sakai, Satoko
著者
木本, 貴士
著者別名
  • キモト, タカシ
  • Kimoto, Takashi
著者
Kim, Hyejin
著者
木戸, 博
著者別名
  • キド, ヒロシ
  • Kido, Hiroshi
学位授与大学
徳島大学
取得学位
博士(医学)
学位授与番号
甲医第1356号
学位授与年月日
2018-01-25

説明

The influenza A virus (IAV)–cytokine–trypsin/matrix metalloproteinase-9 (MMP-9) cycle is one of the important mechanisms of multiple organ failure in severe influenza. Clarithromycin, a macrolide antibiotic, has immune modulatory and anti-inflammatory effects. We analyzed the effects of clarithromycin on the induction of chemokines, cytokines, MMP-9, trypsin, vascular hyper-permeability and inflammatory aggravation in mice with IAV infection. IAV/Puerto Rico/8/34(H1N1) infection increased the levels of monocyte chemoattractant protein- 1 (MCP-1) and cytokines in serum, and MMP-9 and trypsin in serum and/or the lungs and heart. Clarithromycin significantly suppressed the induction of serum MCP-1 and MMP-9 and vascular hyperpermeability in these organs in the early phase of infection, but did not suppress the induction of trypsin, IL-6 or IFN-γ. Histopathological examination showed that clarithromycin tended to reduce inflammatory cell accumulation in the lungs and heart. These results suggest that clarithromycin suppresses infection-related inflammation and reduces vascular hyperpermeability by suppressing the induction of MCP-1 and MMP-9.

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