Discrepancy between systolic and diastolic dysfunction of the left ventricle in patients with Duchenne muscular dystrophy

Takenaka, Akira, Yokota, Mitsuhiro, Iwase, Masatsugu, Miyaguchi, Kazuhiko, Hayashi, Hiroshi, Saito, Hidehiko, 竹中, 晃, 横田, 充弘, 岩瀬, 正嗣, 宮口, 和彦, 林, 博史, 斎藤, 英彦

doi:10.11501/3067268

書誌事項

タイトル: Discrepancy between systolic and diastolic dysfunction of the left ventricle in patients with Duchenne muscular dystrophy

著者: Takenaka, Akira

著者: Yokota, Mitsuhiro

著者: Iwase, Masatsugu

著者: Miyaguchi, Kazuhiko

著者: Hayashi, Hiroshi

著者: Saito, Hidehiko

著者: 竹中, 晃

著者: 横田, 充弘

著者: 岩瀬, 正嗣

著者: 宮口, 和彦

著者: 林, 博史

著者: 斎藤, 英彦

学位授与大学: 名古屋大学

取得学位: 博士(医学)

学位授与番号: 乙第4351号

学位授与年月日: 1993-05-01

説明

To assess the systolic and diastolic dysfunction of the left ventricle (LV) in relation to age and the severity of impairment in Duchenne muscular dystrophy (DMD), we performed M-mode, two-dimensional and pulsed-wave Doppler echocardi-ography in 45 male subjects with DMD aged 8 to 25 years and in 40 age-matched healthy controls. Systolic dysfunction started in the first decade of life, with some patients showing severe systolic dysfunction in their early teens. This dysfunction, however, did not always depend on the severity of the skeletal muscle disease. No patients with DMD showed an increase in peak atrial velocity and time-velocity integrals of the atrial contraction velocity curve, findings frequently reported to precede the abnormalities in many cardiac diseases; it was thought therefore that these patients had no increase in left atrial compensation. Diastolic dysfunction may not routinely precede or accompany the systolic dysfunction in DMD, in contrast with what is reported in patients with ischaemic or hypertensive heart disease. DMD patients usually show a predominant systolic dysfunction.

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