A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population
説明
Lung adenocarcinoma is the most common histological type of lung cancer, and its incidence is increasing worldwide. To identify genetic factors influencing risk of lung adenocarcinoma, we conducted a genome-wide association study and two validation studies in the Japanese population comprising a total of 6,029 individuals with lung adenocarcinoma (cases) and 13,535 controls. We confirmed two previously reported risk loci, 5p15.33 (rs2853677, P(combined) = 2.8 × 10(-40), odds ratio (OR) = 1.41) and 3q28 (rs10937405, P(combined) = 6.9 × 10(-17), OR = 1.25), and identified two new susceptibility loci, 17q24.3 (rs7216064, P(combined) = 7.4 × 10(-11), OR = 1.20) and 6p21.3 (rs3817963, P(combined) = 2.7 × 10(-10), OR = 1.18). These data provide further evidence supporting a role for genetic susceptibility in the development of lung adenocarcinoma.
収録刊行物
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- Nature Genetics
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Nature Genetics 44 (8), 900-903, 2012-07-15
Springer Science and Business Media LLC
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キーワード
詳細情報 詳細情報について
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- CRID
- 1360002216806309248
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- DOI
- 10.1038/ng.2353
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- ISSN
- 15461718
- 10614036
- http://id.crossref.org/issn/10614036
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- PubMed
- 22797724
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- データソース種別
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- Crossref
- KAKEN
- OpenAIRE
