Nuclear Localization of COX-2 in relation to the Expression of Stemness Markers in Urinary Bladder Cancer

DOI DOI DOI DOI PDF ほか5件をすべて表示 一部だけ表示 被引用文献13件 参考文献90件
  • Raynoo Thanan
    Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science, 3500-3 Minamitamagaki-cho, Suzuka, Mie 513-8670, Japan
  • Mariko Murata
    Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan
  • Ning Ma
    Faculty of Health Science, Suzuka University of Medical Science, Suzuka, Mie 510-0293, Japan
  • Olfat Hammam
    Departments of Pathology and Urology, Theodor Bilharz Research Institute, Giza, Egypt
  • Mohamed Wishahi
    Departments of Pathology and Urology, Theodor Bilharz Research Institute, Giza, Egypt
  • Tarek El Leithy
    Departments of Pathology and Urology, Theodor Bilharz Research Institute, Giza, Egypt
  • Yusuke Hiraku
    Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan
  • Shinji Oikawa
    Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan
  • Shosuke Kawanishi
    Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science, 3500-3 Minamitamagaki-cho, Suzuka, Mie 513-8670, Japan

書誌事項

公開日
2012
資源種別
journal article
権利情報
  • http://creativecommons.org/licenses/by/3.0/
DOI
  • 10.1155/2012/165879
  • 10.1016/j.bbrc.2012.03.152
  • 10.60692/tm4hp-xdv63
  • 10.60692/196ym-62b74
公開者
Wiley

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説明

<jats:p>Inflammation may activate stem cells via prostaglandin E2 (PGE2) production mediated by cyclooxygenase-2 (COX-2) expression. We performed an immunohistochemical analysis of the expression of stemness markers (Oct3/4 and CD44v6) and COX-2 in urinary bladder tissues obtained from cystitis and cancer patients with and without<jats:italic>Schistosoma haematobium</jats:italic>infections. Immunoreactivity to Oct3/4 was significantly higher in<jats:italic>S. haematobium</jats:italic>-associated cystitis and cancer tissues than in normal tissues. CD44v6 expression was significantly higher in bladder cancer without<jats:italic>S. haematobium</jats:italic>than in normal tissues. COX-2 was located in the cytoplasmic membrane, cytoplasm, and nucleus of the cancer cells. Interestingly, the nuclear localization of COX-2, which was reported to function as a transcription factor, was significantly associated with the upregulation of Oct3/4 and CD44v6 in bladder cancer tissues with and without<jats:italic>S. haematobium</jats:italic>infection, respectively. COX-2 activation may be involved in inflammation-mediated stem cell proliferation/differentiation in urinary bladder carcinogenesis.</jats:p>

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