抄録
<jats:title>Abstract</jats:title><jats:p>The asymmetric hydrogenation of pyrimidines proceeded with high enantioselectivity (up to 99 % <jats:italic>ee</jats:italic>) using an iridium catalyst composed of [IrCl(cod)]<jats:sub>2</jats:sub>, a ferrocene‐containing chiral diphosphine ligand (Josiphos), iodine, and Yb(OTf)<jats:sub>3</jats:sub> (cod=1,5‐cyclooctadiene). The chiral catalyst converted various 4‐substituted pyrimidines into chiral 1,4,5,6‐tetrahydropyrimidines in high yield. The lanthanide triflate is crucial for achieving the high enantioselectivity as well as for activating the heteroarene substrate.</jats:p>
収録刊行物
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- Angewandte Chemie International Edition
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Angewandte Chemie International Edition 54 (8), 2393-2396, 2015-01-07
Wiley
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詳細情報 詳細情報について
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- CRID
- 1360004229921501568
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- ISSN
- 15213773
- 14337851
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- データソース種別
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- Crossref
- KAKEN