All-trans retinoic acid combined with 5-Aza-2′-deoxycitidine induces C/EBPα expression and growth inhibition in MLL-AF9-positive leukemic cells
書誌事項
- 公開日
- 2012-11
- 資源種別
- journal article
- 権利情報
-
- https://www.elsevier.com/tdm/userlicense/1.0/
- https://www.elsevier.com/legal/tdmrep-license
- DOI
-
- 10.1016/j.bbrc.2012.09.131
- 公開者
- Elsevier BV
この論文をさがす
説明
The present study tested whether all-trans retinoic acid (ATRA) and 5-Aza-2'-deoxycitidine (5-Aza) affect AML cell differentiation and growth in vitro by acting on the CCAAT/enhancer binding protein α (C/EBPα) and c-Myc axis. After exposure to a combination of these agents, cell differentiation and growth arrest were significantly higher in human and murine MLL-AF9-expressing cells than in MLL-AF4/AF5q31-expressing cells, which were partly associated with increased expression of C/EBPα, C/EBPε, and PU.1, and decreased expression of c-Myc. These findings indicate that MLL-AF9-expressing cells are more sensitive to ATRA and 5-Aza, indicating that different MLL fusion proteins possess different epigenetic properties associated with retinoic acid pathway inactivation.
収録刊行物
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- Biochemical and Biophysical Research Communications
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Biochemical and Biophysical Research Communications 428 (2), 216-223, 2012-11
Elsevier BV
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キーワード
- Oncogene Proteins, Fusion
- Nuclear Proteins
- Tretinoin
- Histone-Lysine N-Methyltransferase
- DNA Methylation
- Hematopoietic Stem Cells
- Leukemia, Myeloid, Acute
- Mice
- Drug Resistance, Neoplasm
- Cell Line, Tumor
- Azacitidine
- CCAAT-Enhancer-Binding Protein-alpha
- Animals
- Humans
- Myeloid-Lymphoid Leukemia Protein
- Cell Proliferation
詳細情報 詳細情報について
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- CRID
- 1360004232000606976
-
- ISSN
- 0006291X
-
- PubMed
- 23063977
-
- 資料種別
- journal article
-
- データソース種別
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- Crossref
- KAKEN
- OpenAIRE
