Miuramides A and B, Trisoxazole Macrolides from a <i>Mycale</i> sp. Marine Sponge That Induce a Protrusion Phenotype in Cultured Mammalian Cells
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- Rei Suo
- Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
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- Kentaro Takada
- Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
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- Hisanori Kohtsuka
- Misaki Marine Biological Station (MMBS), Graduate School of Science and Center for Marine Biology, The University of Tokyo, Misaki, Miura, Kanagawa 238-0225, Japan
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- Yuji Ise
- Sugashima Marine Biological Laboratory, Graduate School of Science, Nagoya University, Toba, Mie 517-0004, Japan
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- Shigeru Okada
- Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
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- Shigeki Matsunaga
- Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
書誌事項
- 公開日
- 2018-04-03
- 資源種別
- journal article
- DOI
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- 10.1021/acs.jnatprod.8b00101
- 公開者
- American Chemical Society (ACS)
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説明
Morphology-guided cell-based screening of the extract of a Mycale sp. marine sponge led to the isolation of two trisoxazole macrolides, miuramides A (1) and B (2), which induced characteristic morphological changes in 3Y1 cells. The structure of 1 including absolute configuration was elucidated by a combination of the analysis of spectroscopic data, derivatization, and degradation. Both compounds exhibit potent cytotoxicity against 3Y1 cells.
収録刊行物
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- Journal of Natural Products
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Journal of Natural Products 81 (4), 1108-1112, 2018-04-03
American Chemical Society (ACS)
