Oral Cnm-positive Streptococcus Mutans Expressing Collagen Binding Activity is a Risk Factor for Cerebral Microbleeds and Cognitive Impairment
書誌事項
- 公開日
- 2016-12-09
- 資源種別
- journal article
- 権利情報
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- https://creativecommons.org/licenses/by/4.0
- https://creativecommons.org/licenses/by/4.0
- DOI
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- 10.1038/srep38561
- 公開者
- Springer Science and Business Media LLC
説明
<jats:title>Abstract</jats:title><jats:p>Cerebral microbleeds (CMBs) are an important risk factor for stroke and dementia. We have shown that the collagen binding surface Cnm protein expressed on <jats:italic>cnm</jats:italic>-positive <jats:italic>Streptococcus mutans</jats:italic> is involved in the development of CMBs. However, whether the collagen binding activity of <jats:italic>cnm</jats:italic>-positive <jats:italic>S. mutans</jats:italic> is related to the nature of the CMBs or to cognitive impairment is unclear. Two-hundred seventy nine community residents (70.0 years) were examined for the presence or absence of <jats:italic>cnm</jats:italic>-positive <jats:italic>S. mutans</jats:italic> in the saliva by PCR and collagen binding activity, CMBs, and cognitive function were evaluated. Cnm-positive <jats:italic>S. mutans</jats:italic> was detected more often among subjects with CMBs (p < 0.01) than those without. The risk of CMBs was significantly higher (odds ratio = 14.3) in the group with <jats:italic>S. mutans</jats:italic> expressing collagen binding activity, as compared to the group without that finding. Deep CMBs were more frequent (67%) and cognitive function was lower among subjects with <jats:italic>cnm</jats:italic>-positive <jats:italic>S. mutans</jats:italic> expressing collagen binding activity. This work supports the role of oral health in stroke and dementia and proposes a molecular mechanism for the interaction.</jats:p>
収録刊行物
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- Scientific Reports
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Scientific Reports 6 (1), 38561-, 2016-12-09
Springer Science and Business Media LLC
