GTPases involved in bacterial ribosome maturation

DOI PDF PubMed 参考文献113件 オープンアクセス

書誌事項

公開日
2013-03-17
資源種別
journal article
DOI
  • 10.1093/jb/mvt022
公開者
Oxford University Press (OUP)

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説明

The ribosome is an RNA- and protein-based macromolecule having multiple functional domains to facilitate protein synthesis, and it is synthesized through multiple steps including transcription, stepwise cleavages of the primary transcript, modifications of ribosomal proteins and RNAs and assemblies of ribosomal proteins with rRNAs. This process requires dozens of trans-acting factors including GTP- and ATP-binding proteins to overcome several energy-consuming steps. Despite accumulation of genetic, biochemical and structural data, the entire process of bacterial ribosome synthesis remains elusive. Here, we review GTPases involved in bacterial ribosome maturation.

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