書誌事項
- 公開日
- 2016-12-21
- 資源種別
- journal article
- DOI
-
- 10.1093/jb/mvw074
- 公開者
- Oxford University Press (OUP)
この論文をさがす
説明
The Hippo signalling pathway monitors cell-cell contact and external factors that shape tissue structure. In mice, tumourigenesis and developmental abnormalities are common consequences of dysregulated Hippo signalling. Expression of Hippo pathway components is also frequently altered in human tumours and correlates with poor prognosis and reduced patient survival. Thus, the Hippo pathway is an attractive anti-cancer target. Here, we provide an overview of the function and regulation of Hippo signalling components and summarize progress to date on the development of agents able to regulate Hippo signalling for cancer therapy.
収録刊行物
-
- Journal of Biochemistry
-
Journal of Biochemistry mvw074-, 2016-12-21
Oxford University Press (OUP)
