Phlebotomy as a preventive measure for crocidolite‐induced mesothelioma in male rats
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- Yuuki Ohara
- Department of Pathology and Biological Responses Nagoya University Graduate School of Medicine Nagoya Japan
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- Shan‐Hwu Chew
- Department of Pathology and Biological Responses Nagoya University Graduate School of Medicine Nagoya Japan
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- Takahiro Shibata
- Department of Pathology and Biological Responses Nagoya University Graduate School of Medicine Nagoya Japan
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- Yasumasa Okazaki
- Department of Pathology and Biological Responses Nagoya University Graduate School of Medicine Nagoya Japan
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- Kyoko Yamashita
- Department of Pathology and Biological Responses Nagoya University Graduate School of Medicine Nagoya Japan
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- Shinya Toyokuni
- Department of Pathology and Biological Responses Nagoya University Graduate School of Medicine Nagoya Japan
書誌事項
- 公開日
- 2018-01-04
- 資源種別
- journal article
- 権利情報
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- http://creativecommons.org/licenses/by-nc/4.0/
- DOI
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- 10.1111/cas.13460
- 公開者
- Wiley
この論文をさがす
説明
<jats:p>Malignant mesothelioma (MM) is a rare but socially important neoplasm due to its association with asbestos exposure. Malignant mesothelioma is difficult to diagnose at an early stage, yet there are no particularly effective treatments available at the advanced stage, thus necessitating efficient strategies to prevent MM in individuals already exposed to asbestos. We previously showed that persistent oxidative damage caused by foreign body reaction and affinity of asbestos both to hemoglobin and histones is one of the major pathogeneses. Accordingly, as an effective strategy to prevent asbestos‐induced MM, we undertook the use of an iron chelator, deferasirox, which decreased the epithelial–mesenchymal transition in a crocidolite‐induced rat MM model. However, this agent may show adverse effects. Here, we studied the effects of iron removal by phlebotomy as a realistic measure on the same rat model. We injected a total of 5 mg crocidolite i.p. to F1 hybrid rats between the Fischer‐344 and Brown‐Norway strains at the age of 6 weeks. We repeated weekly or biweekly phlebotomy of 6‐8 mL/kg/time from 10 to 60 weeks of age. The animals were observed until 120 weeks. In male rats, phlebotomy significantly decreased the weight and nuclear grade of MM, and modestly reduced the associated ascites and the fraction of more malignant sarcomatoid subtype. Weekly phlebotomy prolonged long‐term survival. Our results indicate that appropriate phlebotomy may be a practical preventive measure to attenuate the initiation and promotion capacity of asbestos towards MM by reducing iron in individuals exposed to asbestos.</jats:p>
収録刊行物
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- Cancer Science
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Cancer Science 109 (2), 330-339, 2018-01-04
Wiley
