MAIT cells are activated and accumulated in the inflamed mucosa of ulcerative colitis
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- Keiichi Haga
- Departments of Immunology Juntendo University School of Medicine Tokyo Japan
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- Asako Chiba
- Departments of Immunology Juntendo University School of Medicine Tokyo Japan
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- Tomoyoshi Shibuya
- Department of Gastroenterology Juntendo University School of Medicine Tokyo Japan
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- Taro Osada
- Department of Gastroenterology Juntendo University School of Medicine Tokyo Japan
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- Dai Ishikawa
- Department of Gastroenterology Juntendo University School of Medicine Tokyo Japan
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- Tomohiro Kodani
- Department of Gastroenterology Juntendo University School of Medicine Tokyo Japan
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- Osamu Nomura
- Department of Gastroenterology Juntendo University School of Medicine Tokyo Japan
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- Sumio Watanabe
- Department of Gastroenterology Juntendo University School of Medicine Tokyo Japan
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- Sachiko Miyake
- Departments of Immunology Juntendo University School of Medicine Tokyo Japan
書誌事項
- 公開日
- 2016-04-28
- 資源種別
- journal article
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1111/jgh.13242
- 公開者
- Wiley
この論文をさがす
説明
<jats:title>Abstract</jats:title><jats:sec><jats:title>Background and Aim:</jats:title><jats:p>Ulcerative colitis (UC) is a chronic, relapsing and remitting, inflammatory disorder of the large intestine. Mucosal associated invariant T (MAIT) cells are a member of innate‐like lymphocytes found abundantly in the mucosal tissue. The contribution of MAIT cells in the pathogenesis of UC is still unclear; therefore, this study aimed at investigating the role of these cells in patients with UC.</jats:p></jats:sec><jats:sec><jats:title>Methods:</jats:title><jats:p>The frequency of MAIT cells, as well as the production of cytokines and expression levels of activation markers by these cells in the peripheral blood of UC patients and healthy controls, was analyzed by flow cytometry. MAIT cells were also quantified in colon biopsies of UC patients using a confocal microscope.</jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p>There was a significant reduction in MAIT cell frequency in the peripheral blood of UC patients compared with healthy controls (<jats:italic>P</jats:italic> < 0.0001). MAIT cells from UC patients secreted more interleukin (IL)‐17 than healthy controls (<jats:italic>P</jats:italic> < 0.05). The expression levels of CD69 on these cells were correlated with disease activity and endoscopic scores and plasma levels of IL‐18. Furthermore, MAIT cells increased in the inflamed mucosa, and their frequency was correlated with clinical and endoscopic disease activity in UC patients.</jats:p></jats:sec><jats:sec><jats:title>Conclusions:</jats:title><jats:p>The findings from this study indicate that MAIT cells could be associated with UC and may serve as potential biomarkers or therapeutic targets in UC.</jats:p></jats:sec>
収録刊行物
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- Journal of Gastroenterology and Hepatology
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Journal of Gastroenterology and Hepatology 31 (5), 965-972, 2016-04-28
Wiley
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キーワード
- Adult
- Antigens, Differentiation, T-Lymphocyte
- Male
- Colon
- Lymphocyte Activation
- Severity of Illness Index
- Mucosal-Associated Invariant T Cells
- Antigens, CD
- Humans
- Lectins, C-Type
- Intestinal Mucosa
- Cell Death
- Middle Aged
- Immunity, Innate
- Chemotaxis, Leukocyte
- Case-Control Studies
- Cytokines
- Colitis, Ulcerative
- Female
- Inflammation Mediators
- Biomarkers
詳細情報 詳細情報について
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- CRID
- 1360004235779440128
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- ISSN
- 14401746
- 08159319
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- PubMed
- 26590105
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- 資料種別
- journal article
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- データソース種別
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- Crossref
- KAKEN
- OpenAIRE
